Activated charcoal, emesis, and gastric lavage in aspirin overdose

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Activated charcoal, emesis, and gastric lavage in aspirin overdose.

It is common practice to try to prevent intestinal absorption of ingested poisons. Controversy continues about the relative effectiveness of charcoal, ipecacuanha, and lavage in salicylate overdose,' but no study has yet compared all three methods. This study of simulated aspirin overdose in volunteers aimed to compare the effectiveness of gastric lavage, emesis induced by ipecacuanha, and acti...

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A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

The aim of this prospective trial was to compare the efficacy of gastric lavage, activated charcoal and ipecacuanha at limiting the absorption of paracetamol in overdose and to assess the significance of the continued absorption of paracetamol following treatment. Patients aged 16 and over who had ingested 5 gms or more of paracetamol within 4h of admission were entered into the trial. The perc...

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Activated charcoal for acute overdose: a reappraisal.

Sometimes mistakenly characterized as a 'universal antidote,' activated charcoal (AC) is the most frequently employed method of gastrointestinal decontamination in the developed world. Typically administered as a single dose (SDAC), its tremendous surface area permits the binding of many drugs and toxins in the gastrointestinal lumen, reducing their systemic absorption. Like other decontaminati...

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Indications for single-dose activated charcoal administration in acute overdose.

PURPOSE OF REVIEW Gastrointestinal decontamination in overdose patients remains a controversial problem in emergency medicine. There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low. RECENT FINDINGS Human volunteer studies suggest SDAC is effec...

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Case report of aspirin overdose: bezoar formation and controversies of multiple-dose activated charcoal in salicylate poisoning

Bezoar formation is cited to be the cause of delayed absorption of aspirin in overdose of enteric-coated aspirin preparation. However, such phenomenon from oral overdose of regular aspirin preparation has not been clearly demonstrated in human. The use of multiple-dose activated charcoal (MDAC) in salicylate poisoning remains controversial. We report a case of regular-preparation salicylate poi...

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ژورنال

عنوان ژورنال: BMJ

سال: 1988

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.296.6635.1507